Mengesan Kanser Esofagus
Tumour marker detection in oesophageal
carcinoma.
Levels of the tumour markers CEA, CA 19-9, CA 125 and SCC
were measured in 58 patients presenting with oesophageal carcinoma and compared
with levels in patients with benign oesophageal disease and levels in normal
volunteers.
CEA and CA 19-9 were significantly increased in the patients
with oesophageal cancer, however, individual sensitivity for CEA, CA 19-9, CA
125 and SCC was only 28, 34, 10, and 32%, respectively.
The combined sensitivity of all markers was 64% and
specificity was 80%.
There was no difference in combined tumour marker sensitivity
between squamous or adenocarcinomas of the oesophagus.
No consistent change in marker levels occurred with
treatment, and tumour marker levels could not be significantly correlated with
stage of disease or short-term survival.
These results indicate that tumour marker sensitivity is too
low for oesophageal cancer screening and has poor prognostic significance in
those undergoing treatment.
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