Betulinic Acid
for Cancer Treatment
Betulinic acid is a natural product with a range of
biological effects, for example potent antitumor activity. This anticancer
property is linked to its ability to induce apoptotic cell death in cancer
cells by triggering the mitochondrial pathway of apoptosis. In contrast to the
cytotoxicity of betulinic acid against a variety of cancer types, normal cells
and tissue are relatively resistant to betulinic acid, pointing to a
therapeutic window. Compounds that exert a direct action on mitochondria
present promising experimental cancer therapeutics, since they may trigger cell
death under circumstances in which standard chemotherapeutics fail. Thus,
mitochondrion-targeted agents such as betulinic acid hold great promise as a
novel therapeutic strategy in the treatment of human cancers.
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