Penyakit disebabkan oleh Cadmium

Introduction

Itai-itai disease was found in the cadmium(Cd) polluted Jinzu River basin in Toyama Prefecture, and has been generally recognized since the 1950's by the effort of inhabitants and Dr. Hagino who was a general practitioner with a private clinic in the polluted area.

Itai-itai disease was officially recognized in 1968 as the first disease induced by environmental pollution in Japan after legal proceedings. The basis of the court decision is simply but clearly shown in "The view of the Ministry of Health and Welfare" which consisted of 7 articles and was announced on 8th May, 1968. Especially, the basis that concluded the cause of the disease to be Cd pollution was epidemiological evidence that only cadmium can explain the limited development of itai-itai disease in a specific area around parts of the Jinzu River.

Epidemiology

The degree of Cd pollution in different parts of the endemic area determined by the analyzed Cd concentration of the soil in the paddy fields was shown in Fig.1. In Fig.2, the frequency of the disease is illustrated by the percentage of women over 50 years of age having or suspected of having the disease. The striking correlation between the prevalence of itai-itai disease and degree of Cd pollution was found even within the endemic area.

Itai-itai disease is considered to be a type of acquired Fanconi Syndrome characterized by renal tubular dysfunction and osteomalacia and has been found among middle aged and elderly women with relatively frequent pregnancy, living in the cadmium polluted area for more than 30 years.

A markedly increased excretion of urinary molecular weight proteins such as (β2-microglobulin, glucose, protein and amino acids is found in itai-itai disease patients, and these findings are indices of renal tubular dysfunction. Low level of %TRP and metabolic acidosis with high serum Cl are also found. In severe cases increased serum creatinine that shows impairment of renal glomerular function is recognized.

Pathologically, renal damage of itai-itai disease is characterized by atrophic kidney as shown in Fig.3. The weight of the kidney is usually decreased to around 60g, and to 30g's in cases with non-specific inflammation or atherosclerotic change. Microscopically, tubulopathy is found as shown in Fig.4.

Another specific finding of itai-itai disease is osteomalacia. The remodeling layer called "Looser zone" shown in Fig.5 and Fig.6 is characteristic. Looser zone is often found in femur, pelvis and ribs. Osteoporosis is also associated with X-ray findings such as unclear trabecular pattern and cortial bone thinning noted.

Pathologically, increased osteoid tissue is characteristic of osteomalacia, as shown in Fig.7

Prognosis

Bone damage tends to become refractory in some cases, but to remit by treatment such as vitamin D2 or activated Vitamin D3 treatment as a whole.

However, renal damage progresses to advanced renal failure(Fig.8), and some cases of uremia need hemodialysis. Anemia also develops in proportion to the degree of renal failure.

Survival rate of itai-itai disease patients is significantly lower than that of controls (Fig.9), and especially life prognosis of cases with severe renal damage is unfavorable.

Renal tubular dysfunction is well known as an adverse health effect of environmental cadmium exposure, and is characterized by the increased urinary excretion of low molecular weight proteins such as beta2-microglobulin(β2-MG).

Increased urinary excretion of total protein, glucose and amino acids is also found in the inhabitants living in cadmium polluted areas. Low %TRP(percentage of tubular reabsorption of phosphorus) and metabolic acidosis are found in moderate and severe cases.

Most severe renal damage developing in itai-itai disease patients is accompanied with renal glomerular dysfunction progressing to renal failure.

　 >>> More information about itai-itai disease is available. Click here !

The following map shows the location of cadmium polluted areas in Japan, and the number of subjects, positive rate of urinary cadmium and positive rate of urinary protein and glucose of inhabitants living in each area. Urinary cadmium is an index of cadmium exposure. Although positive rate of urinary protein and glucose is less sensitive than β2-MG for screening of renal tubular dysfunction, you can see that Jinzu River basin in Toyama where itai-itai disease has been found, is the most heavily polluted and affected area by cadmium in Japan.

Kanser daripada sotong kering

Kanser daripada sotong kering - Mengandungi logam toksik sama seperti bateri, plastik dan baja fosfat

KLIK

GEORGE TOWN - Ramai mengetahui keenakan sotong kering ditambah lagi jika dimasak sebagai sambal.

Namun Persatuan Pengguna Pulau Pinang (CAP) mendedahkan, tidak mungkin ramai pengguna sedar bahawa sotong kering kaya dengan logam toksik jenis kadmium, bahan yang sama digunakan dalam membuat bateri, plastik dan baja fosfat.

"Kesan pengambilan kadmium mendedahkan seseorang terhadap kanser payu dara, kanser prostat serta penyakit buah pinggang,'' kata Presidennya, S. M. Mohamed Idris pada sidang media di pejabatnya di sini semalam.

Menurutnya, selain sotong kering, makanan laut kering lain seperti tiram, ikan bilis dan udang juga mengandungi kadmium tetapi pada kadar yang lebih rendah.

"Hasil ujian yang dilakukan mendapati kandungan kadmium dalam sotong kering melebihi empat kali ganda had yang dibenarkan,'' ujarnya.

CAP membuktikan perkara itu melalui ujian rawak melibatkan enam sampel sotong kering dan hasilnya mendapati lima sampel mengandungi kadmium serta tiga daripadanya mempunyai kandungan logam itu secara berlebihan.

Kanser Kulit

Tahukah anda bahawasanya pendedahan terlampau lama kepada cahaya matahari boleh meningkatkan risiko mendapat kanser kulit. Ini ditambah pula sekiranya langit tiada langsung berawan atau lapisan ozon yg menipis di langit anda maka lebih banyaklah pancaran radiasi dari matahari akan hinggap ke badan anda.

Ada 3 jenis radiasi asas ultraviolet iaitu

• UVA (long-wave UV)
• UVB (sunburn UV)
• UVC (short-wave UV)

Ultraviolet Radiation Type	General Features
Ultraviolet A radiation UVA, long-wave UV)	-not filtered out in the atmosphere -passes through glass  -produces some tanning  -once considered harmless but now believed harmful over the long term  -levels remain relatively constant throughout the day
Ultraviolet B radiation  (UVB, sunburn radiation)	-some filtered out in the atmosphere by the ozone layer  -does not pass through glass  -causes sunburn, tanning, wrinkling, aging of the skin and skin cancer  -highest intensity at noontime
Ultraviolet C radiation  (UVC, short-wave UV)	-filtered out in the atmosphere by the ozone layer before reaching earth  -major artificial sources are germicidal lamps (to kill bacteria)  -burns the skin and causes skin cancer

Untuk keterangan lanjut sila  klik skin_cancer

herbs provide powerful protection against liver cancer

Science proves these seven herbs provide powerful protection against liver cancer and liver damage of all kinds

medicinal_herbs_natural_treatments_reversing_cancer

medicinal_herbs_natural_treatments_reversing_cancer

(NaturalNews) More than 10 percent of the world's population currently suffers from some form of liver disease, whether it be fibrosis, cirrhosis, a hepatocellular carcinoma, alcoholic steatosis, or chronic hepatitis. And a great number of these folks use some kind of natural remedy as treatment rather than pharmaceuticals, according to a 2012 study published in theEuropean Journal of Medicinal Chemistry.

Herbal remedies have gained an incredible following among liver disease sufferers, because they're safe and highly effective, without all the harmful side effects. According to the paper, the following herbs and herb-derived remedies are among the top contenders in this natural fight against liver disease:

1) Curcumin (Curcuma longa). This turmeric derivative has been used throughout Southeast Asia as a remedy for rheumatism, skin diseases, body aches, intestinal worms, diarrhea and hepatic disorders. More recently, curcumin has shown scientific benefits in treating inflammatory diseases like diabetes, heart disease, arthritis, dementia and cancer.

"Curcumin could attenuate liver injury induced by ethanol [alcohol], thioacetamide, iron overdose, cholestasis and acute, subchronic and chronic carbon tetrachloride (CCl4) intoxication," explains the paper. "[M]oreover, it can reverse CCl4 cirrhosis to some extent."

2) Wogonin (Scutellaria radix). This monoflavonoid compound isolated from skullcap root shows incredible promise in the treatment of both Hepatitis B and C, as well as various forms of alcoholic and non-alcoholic fatty liver disease. Unlike pharmaceuticals, wogonin doesn't promote drug resistance, nor does it induce adverse events in patients.

"The anti-HBV activity of wogonin demonstrates its ability to suppress hepatitis B surface antigen secretion in cell culture," the study highlights, noting that wogonin has also been shown to be effective in treating hepatocellular carcinoma cells.

3) Glycyrrhizin (Glycyrrhiza glabra). This active constituent of licorice root has long been used in the treatment of chronic hepatitis, and also possesses a host of natural anti-inflammatory and antiviral properties. Glycyrrhizin is used in traditional Chinese medicine to protect liver function and also to combat tumors.

4) Resveratrol. This polyphenolic phytochemical derived from berries, grapes and wine, has gained itself a solid reputation as one of the most potent anti-aging compounds found in nature. But resveratrol has also been shown scientifically to have hepatoprotective properties that may help protect against hepatic damage caused by free radicals and inflammatory cytokines. It also helps elevate levels of glutathione in the body and promote the formation of antioxidant enzymes, both of which help protect the liver.

5) Silymarin (Silybum marianum). This compound derived from milk thistle is arguably the most well-studied in the natural treatment of liver disease. Milk thistle extract has long held a strong reputation as one of the most powerful "liver tonics" in the world, due to its amazing ability to prevent and/or reverse hepatotoxicity caused by drugs and other toxins. Silymarin also helps combat the production of free radicals, as well as exerting antifibrotic activity that helps protect the liver against toxic damage.

6) Rhein. This anthraquinone derived from rhubarb is known to have powerful anti-cancer properties. But it's also an amazing remedy in the treatment and prevention of fatty liver disease. Its antioxidant and anti-inflammatory properties have also shown benefits in protecting against hepatic fibrosis by inhibiting the expression of both TGF-beta1 and hepatic stellate cells, both of which are markers in the progression of liver disease.

7) Geniposide (Gardenia jasminoides). This compound of the gardenia plant is particularly beneficial in treating hyperlipidemia and fatty liver disease. Studies have shown that geniposide is particularly effective at inhibiting liver fibrosis, as well as protecting against hepatic steatosis.

"Genipin could induces [sic] apoptotic cell death in rat hepatoma cells and human hepatocarcinoma Hep3B cells," the study explains.

Ginger over chemo

This powerful root can eliminate 10,000x the number of cancer cells

ginger_chemotherapy_cancer_cells

(NaturalNews) Inflammation was proven time and time again to be one of the fundamental processes that accelerate illnesses or even cause them to begin with. In basic mechanical interactions, when our body perceives a threat inside of it, it triggers inflammation as a defense mechanism. Together with free radicals, inflammation kills cells in our body. But it doesn't stop at the bad guys. In fact, inflammation is also responsible for extensive friendly-fire at a cellular level.

Our immune system doesn't always discern between actual threats and false-positives. What's worse, long-term inflammation is especially harmful for our bodies, exposing us to a host of diseases and shortening our life-span. Therefore, it's only natural to assume that antioxidant rich foods are an essential-part of our long term health and well-being. If you weren't convinced that the right food can cure you, then you probably didn't know that ginger is one of the most effective anti-cancer cures. How effective? 10,000 times more effective than chemo.

The facts from Georgia State

Ever since inflammation was proven to contribute to the on-set and development of the majority of diseases, researchers have been investigating plants that are rich in antioxidants in order to ascertain their effectiveness in both curing and preventing of sickness. Turmeric was among the first ones on the list and its impact in various types of cancer, as well as a swarm of other diseases, is now undeniable. Ginger is a close relative of turmeric, so scientists thought it might be a good idea to take a closer look at its healing properties. Georgia State University did just that in a trial that involved prostate cancer in mice.

What the scientists found out was awe-inspiring. The mice experienced a reduction in the size of prostate tumors by as much as 56% when taking 6-shoagoal, a pungent compound in ginger that is produced when the root is dried or cooked. By comparison to the treatment of control subjects, ginger proved to be a staggering 10,000x stronger. But the good news doesn't stop here. Particularly when it comes to prostate cancer, this root helps patients avoid death, unlike the chemotherapy that promotes a weakened immune system and even the metastasis of cancer.

With chemo, living tissue is bombarded with chemicals and cells die. However, as a result of the local damage, there is a significant possibility that the tumors will come back with a vengeance and spread throughout the body. Most of the times, this is what happens when a patient undergoes chemotherapy, which is why some in the medical community are so eager to find better treatments that are less likely to worsen an individual's state.

The hand that heals you

Regardless of how medicine tries to manipulate cancer, it never seems to get better. Maybe the cure lies elsewhere. It's quite disturbing that thousands of oncologists around the world still recommend drugs to patients who are in the early stages of this disease, especially since nature has given us the strength and means to fight off most of the illnesses we are faced with. In spite of this, we persist to cling on to chemicals that are not only ineffective but also highly likely to generate even more damage.

Besides slowing down cancer, ginger was proven to be effective for over 100 other ailments, including diabetes, osteoarthritis and chemotherapy-induced nausea. Another good reason why you should definitely try it is the fact that it comes with virtually no side effects. Unlike chemo, ginger acts like as a remedy. Chinese medicine started using it to treat patients over 2,000 year ago. Surely they didn't just discover it and then continued to use it in clinical circumstances for no reason.

While it may be some time before general practitioners examine patients and write a nutritional prescription that addresses their diet, we're definitely getting closer. Drugs and chemicals generally do more harm than good to our long-term health, so why not help the immune system fight illnesses on its own, the way it's meant to?

Klik    ginger_chemotherapy_cancer_cells

Ginger over chemo:

This powerful root can eliminate 10,000x the number of cancer cells

ginger_chemotherapy_cancer_cells

(NaturalNews) Inflammation was proven time and time again to be one of the fundamental processes that accelerate illnesses or even cause them to begin with. In basic mechanical interactions, when our body perceives a threat inside of it, it triggers inflammation as a defense mechanism. Together with free radicals, inflammation kills cells in our body. But it doesn't stop at the bad guys. In fact, inflammation is also responsible for extensive friendly-fire at a cellular level.

Our immune system doesn't always discern between actual threats and false-positives. What's worse, long-term inflammation is especially harmful for our bodies, exposing us to a host of diseases and shortening our life-span. Therefore, it's only natural to assume that antioxidant rich foods are an essential-part of our long term health and well-being. If you weren't convinced that the right food can cure you, then you probably didn't know that ginger is one of the most effective anti-cancer cures. How effective? 10,000 times more effective than chemo.

The facts from Georgia State

Ever since inflammation was proven to contribute to the on-set and development of the majority of diseases, researchers have been investigating plants that are rich in antioxidants in order to ascertain their effectiveness in both curing and preventing of sickness. Turmeric was among the first ones on the list and its impact in various types of cancer, as well as a swarm of other diseases, is now undeniable. Ginger is a close relative of turmeric, so scientists thought it might be a good idea to take a closer look at its healing properties. Georgia State University did just that in a trial that involved prostate cancer in mice.

What the scientists found out was awe-inspiring. The mice experienced a reduction in the size of prostate tumors by as much as 56% when taking 6-shoagoal, a pungent compound in ginger that is produced when the root is dried or cooked. By comparison to the treatment of control subjects, ginger proved to be a staggering 10,000x stronger. But the good news doesn't stop here. Particularly when it comes to prostate cancer, this root helps patients avoid death, unlike the chemotherapy that promotes a weakened immune system and even the metastasis of cancer.

With chemo, living tissue is bombarded with chemicals and cells die. However, as a result of the local damage, there is a significant possibility that the tumors will come back with a vengeance and spread throughout the body. Most of the times, this is what happens when a patient undergoes chemotherapy, which is why some in the medical community are so eager to find better treatments that are less likely to worsen an individual's state.

The hand that heals you

Regardless of how medicine tries to manipulate cancer, it never seems to get better. Maybe the cure lies elsewhere. It's quite disturbing that thousands of oncologists around the world still recommend drugs to patients who are in the early stages of this disease, especially since nature has given us the strength and means to fight off most of the illnesses we are faced with. In spite of this, we persist to cling on to chemicals that are not only ineffective but also highly likely to generate even more damage.

Besides slowing down cancer, ginger was proven to be effective for over 100 other ailments, including diabetes, osteoarthritis and chemotherapy-induced nausea. Another good reason why you should definitely try it is the fact that it comes with virtually no side effects. Unlike chemo, ginger acts like as a remedy. Chinese medicine started using it to treat patients over 2,000 year ago. Surely they didn't just discover it and then continued to use it in clinical circumstances for no reason.

While it may be some time before general practitioners examine patients and write a nutritional prescription that addresses their diet, we're definitely getting closer. Drugs and chemicals generally do more harm than good to our long-term health, so why not help the immune system fight illnesses on its own, the way it's meant to?

Klik    ginger_chemotherapy_cancer_cells

Stage IV breast cancer got rid of Cancer

Klik Here

Trust the doctor. Thank you for the support of family.

CARGULLO JEAN BUENA is a teacher from the Philippines. She loves her job and is passionate in her dream of sharing knowledge to the youth, the hope of the country. She was going on with her daily routine when in 2008, she found out that there was a thumb-sized lump in her right breast. During that time, she did not feel any discomfort so she did not seek any medical treatment. Until in 2012, when she underwent a regular check-up and found that the lump grew as large as a fist. After taking biopsy in 2013, she was diagnosed with breast cancer. The news surprised JEAN because she did not experience any symptoms or pain. The local doctor advised her to undergo surgery to remove the whole breast but she wanted to save her breast so she refused. Thus, her husband looked for other treatment options for JEAN.

JEAN’s husband said, “In the Philippines, the common treatments for breast cancer are surgery, radiotherapy and chemotherapy. Coincidently, I learned about Modern Cancer Hospital Guangzhou so I was given a glimmer of hope thus I read more about the cancer treatments at Modern Cancer Hospital Guangzhou. I learned about the many cancer treatment options available, such ascryotherapy, interventional therapy and other new therapies which are suitable for my wife because these treatments are minimally invasive, bring smaller trauma, and has lesser side effects. Thus, I suggested to my wife to take treatment here.”

JEAN learned that in minimally invasive treatment, there is no need for open surgery but it still yields the same effect so she decided to give it a try. In May 2013, she took the first treatment atModern Cancer Hospital Guangzhou. The multi-disciplinary team of doctors diagnosed her as soon as possible and the result showed that it was already stage 4, with metastasis of the lymph and of the left breast. Hearing the result made JEAN more worried. With the encouragement of her husband, she underwent the first interventional therapy. Interventional therapy is done under the guidance of medical imaging equipment wherein the anti-cancer drugs are injected directly to the blood supplying artery of the tumor which effectively shrinks the tumor. Compared with the traditional chemotherapy, interventional therapy targets the tumor precisely and brings lesser side effects to the body; the drug concentration of anticancer drug inside the tumor is much higher than the conventional chemotherapy because it is directly infused into the tumor and so it brings better efficacy.

When JEAN took the first interventional therapy, she felt worried when she was lying quietly on the medical machine. One hour passed and the interventional therapy was completed. JEAN said, “Interventional therapy is not as terrifying as I thought it was. I did not feel anything. There was only a little bit of pain at the beginning.”

After two sessions of interventional therapy, the tumor had shrunk. Then JEAN took one session of cryotherapy. Cryotherapy is done by releasing Argon gas to lower the temperature and freeze the tumor and the surrounding tissue; then the He gas is released to thaw the frozen tumor thus destroying it in the process.

After 6 sessions of interventional therapy, one session of cryotherapy and consolidated radiotherapy, the tumor cells in JEAN BUENA CARGULLO’s body have been destroyed and her condition is currently stable and she now returns to work. Two years has passed, JEAN still comes back for regular check-up every year. The attending doctor of JEAN, told us that JEAN is in a good and stable condition and so far there is not a sign of cancer recurrence.